Epidemiological evidence supports the general conclusion of a relationship between diet and cancer. In contrast to cardiovascular disease, for which the link to nutrition is now generally recognized, the relationship between diet and cancer and the role of nurition is less well understood.
One specific problem is the evalation of nutritional biomarkers in cancer, which might be modulated by many different aspects but the dietary intake alone. This includes changes in metabolism, modulation by the tumor site or the inflammatory status. We are currently adressing this question with regard to the usability of transthyretin (TTR) as cancer biomarker in ovarian cancer in cooperation with the Department of Gynecology and Obstetrics Charité Campus Virchow, Berlin.