Renal injury is most likely the result of multiple mechanisms. Metabolic mechanisms interplay with hemodynamic processes using common intermediate pathways that finally result in glomerular and tubular injury, proteinuria and ultimately renal failure.
Proteinuria is also suggested to be an independent risk factor for the progression of renal failure.Therefore, the study of urinary peptide and protein patterns might be a potential approach to find reliable candidates as markers in evaluating kidney physiology and pathophysiology. Our current research activities are directed towards the identification of marker proteins of glomerular and tubular dysfunction during acute and chronic diseases in humans, which are conducted in close collaboration with clinical partners. Moreover, we are seeking for urinary biomarkers in early detection of renal dysfunction in companion animals